90plus 纳米粒度仪应用案例-31
90plus纳米粒度仪应用案例
文献名：compositeglycidylmethacrylateddextran(dex-gma)/gelatinnanoparticlesforlocalizedproteindelivery
作者：fa-mingchen,zhi-weima,guang-yingdongandzhi-fenwu
departmentofperiodontologyandoralmedicine,schoolofstomatology,fourthmilitarymedicaluniversity,xi'an710032,china
departmentofphysiologyanddevelopmentalbiology,provo,ut,usa
摘要：
aim:localizeddeliveryofgrowthfactorshassignificantpotentialasafuturetherapeuticstrategyintissueengineeringandregenerativemedicine.ananoparticlevehiclewascreatedandevaluatedinthisstudywiththeintenttodelivergrowthfactorsforperiodontalregeneration.
methods:novelcompositenanoparticlesbasedonglycidylmethacrylatederivatizeddextrans(dex-gma)andgelatinwerefabricatedbyafacilemethodwithoutusinganyorganicsolvents.theconfigurationsoftheresultantnanoparticleswereevaluatedbytransmissionelectronmicroscopy,scanningelectronmicroscopy,andatomicforcemicroscope.theirsurfaceswerecharacterizedbyzeta-potentialmeasurements,afterwhichtheirpropertiesincludingswelling,degradation,drugrelease,andcytotoxicitywerealsoinvestigatedusinginvitromodels.
results:theparticlesizeofdex-gma/gelatinnanoparticles(dg-nps)rangedfrom20to100nmandshowedamono-dispersesizedistribution(meandiameter53.7nm)andastronglynegativesurfacezetapotential(−20mv).thedg-npswerecharacterizedbygoodswellinganddegradationpropertiesinmediaincludingdextranase.theinvitrodrugreleasestudiesshowedthattheefficientbonemorphogeneticprotein(bmp)releasefromdg-npswasmaintainedformorethan12dunderdegradationconditions,wheremorethan90%oftheloadedbmpwasreleased.noanyrelevantcelldamagecausedbydg-npswasfoundinthecytotoxicitytestsforaperiodof24h.
conclusion:thesecombinedresultsdemonstratethatdg-npsfulfillthebasicprerequisitesforgrowthfactordelivery.withfurtherinvivostudies,thosenanoparticlesmayofferapromisingvehicleforthedeliveryofactivedrugstotheperiodontium.
关键词：drugdeliverysystems,drugcarriers,bonemorphogeneticprotein,periodontalregeneration,growthfactors
垃圾站消除臭味方法—喷雾消毒除臭设备
透明材料的清晰度和表面粗糙度有什么关系
木薯全自动脱皮机特点
JKS碱骨料试验箱技术参数
全中文余氯、总氯、化合氯检测仪
90plus 纳米粒度仪应用案例-31
门窗密封条如何贴比较好？
meister流量开关DKM-2/1/S G1/4工作原理
熔化极气体保护焊接渐取代手工电焊
符合欧标1.4313不锈钢相当于什么材质
沈阳实验台设计离不开的四个基础部件
力士乐 轴向柱塞泵的数字闭环控制电子元件 VT-VPCD
孢子自动捕捉系统工作原理介绍
江苏三星设计制造往复走丝电火花线切割机床
埋地式整体食堂油水分离装置安装视频
百闻不如一见，通快邀您至客户现场感受加工品质
铁苋的功效与作用
GB/T586船用法兰铸钢止回阀 船用法兰铸钢止回阀规格 船用法兰铸钢止回阀参数 船用法兰铸钢止回阀价格
光纤激光器的优势及技术应用
Q644F气动三通球阀之主要特点及流向示意图
文献名：compositeglycidylmethacrylateddextran(dex-gma)/gelatinnanoparticlesforlocalizedproteindelivery
作者：fa-mingchen,zhi-weima,guang-yingdongandzhi-fenwu
departmentofperiodontologyandoralmedicine,schoolofstomatology,fourthmilitarymedicaluniversity,xi'an710032,china
departmentofphysiologyanddevelopmentalbiology,provo,ut,usa
摘要：
aim:localizeddeliveryofgrowthfactorshassignificantpotentialasafuturetherapeuticstrategyintissueengineeringandregenerativemedicine.ananoparticlevehiclewascreatedandevaluatedinthisstudywiththeintenttodelivergrowthfactorsforperiodontalregeneration.
methods:novelcompositenanoparticlesbasedonglycidylmethacrylatederivatizeddextrans(dex-gma)andgelatinwerefabricatedbyafacilemethodwithoutusinganyorganicsolvents.theconfigurationsoftheresultantnanoparticleswereevaluatedbytransmissionelectronmicroscopy,scanningelectronmicroscopy,andatomicforcemicroscope.theirsurfaceswerecharacterizedbyzeta-potentialmeasurements,afterwhichtheirpropertiesincludingswelling,degradation,drugrelease,andcytotoxicitywerealsoinvestigatedusinginvitromodels.
results:theparticlesizeofdex-gma/gelatinnanoparticles(dg-nps)rangedfrom20to100nmandshowedamono-dispersesizedistribution(meandiameter53.7nm)andastronglynegativesurfacezetapotential(−20mv).thedg-npswerecharacterizedbygoodswellinganddegradationpropertiesinmediaincludingdextranase.theinvitrodrugreleasestudiesshowedthattheefficientbonemorphogeneticprotein(bmp)releasefromdg-npswasmaintainedformorethan12dunderdegradationconditions,wheremorethan90%oftheloadedbmpwasreleased.noanyrelevantcelldamagecausedbydg-npswasfoundinthecytotoxicitytestsforaperiodof24h.
conclusion:thesecombinedresultsdemonstratethatdg-npsfulfillthebasicprerequisitesforgrowthfactordelivery.withfurtherinvivostudies,thosenanoparticlesmayofferapromisingvehicleforthedeliveryofactivedrugstotheperiodontium.
关键词：drugdeliverysystems,drugcarriers,bonemorphogeneticprotein,periodontalregeneration,growthfactors
垃圾站消除臭味方法—喷雾消毒除臭设备
透明材料的清晰度和表面粗糙度有什么关系
木薯全自动脱皮机特点
JKS碱骨料试验箱技术参数
全中文余氯、总氯、化合氯检测仪
90plus 纳米粒度仪应用案例-31
门窗密封条如何贴比较好？
meister流量开关DKM-2/1/S G1/4工作原理
熔化极气体保护焊接渐取代手工电焊
符合欧标1.4313不锈钢相当于什么材质
沈阳实验台设计离不开的四个基础部件
力士乐 轴向柱塞泵的数字闭环控制电子元件 VT-VPCD
孢子自动捕捉系统工作原理介绍
江苏三星设计制造往复走丝电火花线切割机床
埋地式整体食堂油水分离装置安装视频
百闻不如一见，通快邀您至客户现场感受加工品质
铁苋的功效与作用
GB/T586船用法兰铸钢止回阀 船用法兰铸钢止回阀规格 船用法兰铸钢止回阀参数 船用法兰铸钢止回阀价格
光纤激光器的优势及技术应用
Q644F气动三通球阀之主要特点及流向示意图