BroadPharm什么是阳离子脂质Cationic Lipids？
what are cationic lipids?cationic lipids are a class of lipid molecules with a permanent positive charged head group with structure as exemplified by molecule dotap (figure 1). because of the structure specialty, cationic lipid are an amphiphilic entity with a head group having hydrophilicity and lipid tails possessing hydrophobicity.
figure 1: structure of dotap
application of cationic lipidthe first publication about cationic lipids to transfect dna into cells was published by philip felgner. currently, cationic lipids have become one of few major class of molecules in lipid nanoparticle (lnp) drug delivery vehicles, mrna vaccine encapsulation. cationic lipids neutralize negative charges and facilitate encapsulation and cell uptake in lipid nanoparticles (lnp). usually unsaturated, short (<30 monomer) hydrocarbon chains of the lipids are associated with the highest transduction efficiencies. in aqueous environments, these lipids form micelles with positively charged surfaces that complex with dna. these lipoplexes act to neutralize charge repulsion between the cell membrane and dna and promote endocytosis, similar to the mechanism of cationic polymers.
lipid supplier and customer synthesisas a leading biochemical supplier worldwide, broadpharm offer a wide array of lipid molecules, such as ionizable lipids, cationic lipids, helper lipids, and peg lipids to our clients worldwide. broadpharm also provides fast speed custom synthesis of novel lipid molecules to empower your advanced research.
journal reference:1. s. simoes, a. filipe, (march 2, 2005). cationic liposomes for gene delivery. expert opinion on drug delivery. 2 (2): 237-254.
2. x. hou, t. zaks, r. langer, y. dong, nature review materials, (2021)
3. b. pitard, d. habrant , supramolecular medicinal chemistry and chemical biology, in comprehensive supramolecular chemistry ii, 2017
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BroadPharm什么是阳离子脂质Cationic Lipids？
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figure 1: structure of dotap
application of cationic lipidthe first publication about cationic lipids to transfect dna into cells was published by philip felgner. currently, cationic lipids have become one of few major class of molecules in lipid nanoparticle (lnp) drug delivery vehicles, mrna vaccine encapsulation. cationic lipids neutralize negative charges and facilitate encapsulation and cell uptake in lipid nanoparticles (lnp). usually unsaturated, short (<30 monomer) hydrocarbon chains of the lipids are associated with the highest transduction efficiencies. in aqueous environments, these lipids form micelles with positively charged surfaces that complex with dna. these lipoplexes act to neutralize charge repulsion between the cell membrane and dna and promote endocytosis, similar to the mechanism of cationic polymers.
lipid supplier and customer synthesisas a leading biochemical supplier worldwide, broadpharm offer a wide array of lipid molecules, such as ionizable lipids, cationic lipids, helper lipids, and peg lipids to our clients worldwide. broadpharm also provides fast speed custom synthesis of novel lipid molecules to empower your advanced research.
journal reference:1. s. simoes, a. filipe, (march 2, 2005). cationic liposomes for gene delivery. expert opinion on drug delivery. 2 (2): 237-254.
2. x. hou, t. zaks, r. langer, y. dong, nature review materials, (2021)
3. b. pitard, d. habrant , supramolecular medicinal chemistry and chemical biology, in comprehensive supramolecular chemistry ii, 2017
铝箔贴面橡塑保温板
食品添加剂 乙酸丙酯-折光指数和相对密度的测定
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